Active Pharmaceutical Ingredient (API) Filtration
We understand the impact improper filtration can have on the pharmaceutical preparations you produce and the overall adverse impact that substandard filtration can have on your business.
Optimizing the API Filtration Process
In the fine chemical industry, it is critical to filter process components to prevent particulate and microbial contamination, helping ensure product sterility and quality. Global Filter’s product solutions help protect the process from contaminants while extending service life and reducing operations costs. Global Filter designs and manufactures filter elements and vessels that are widely used in API filtration. Our expertise in pharmaceutical preparations will help to optimize your manufacturing process.
Typical API Process
Filtration of API Upstream Process
Filtration of raw materials is important to ensure the best productivity during chemical reactions or treatment. Global Filter product range offers solutions to remove contaminants from solids particles to microorganisms from pharmaceutical preparations.
Firstly, for the particulate removal filter, we recommend using Global Filter’s GCTB-Series Meltblown cartridges along with the GTCH cartridge vessel.
Then, for the point-of-use particulate removal filter, we recommend using our pleated depth cartridge (PP-Series) with a GFHD mono cartridge vessel.
Moreover, we advise using a 0.2-micron rating PES membrane cartridge for microbial retention for the point-of-use sterilizing grade filter.
Finally, for the gas filter, it is recommended to use PPTFE-Series (Sterilizing grade) membrane cartridges along with the GSTL sanitary vessel.
Activated Carbon or Catalyst Removal
During production, it could be necessary to add solids such as active carbon or catalysis which
will be removed after the treatment or reaction. Depending on the solid quantity a first main step could be necessary to remove the majority of the catalysts. Amafilter’s Cricket filter is one of the best solutions for this step. For small batches or after the main filtration we also offer several solutions in accordance with your process.
Our HFB-Series High Flow cartridge is one of the recommended solutions as it offers a safer and healthier option. Global Filter’s GHLS- Series pleated depth cartridge offers a reliable solution for catalysis recovery throughout its lifetime and especially after several cycles.
Crystallization and Solvent Filtration
In several steps of the pharmaceutical preparations process, solvents are necessary, and producing high-purity solvents on-site can be really cost-effective. The PP-Series pleated cartridges and GPFA-Series Membrane cartridges with absolute efficiencies down to 0.05 µm with high chemical compatibility are the best solutions to fulfill your requirements in terms of solvent filtration.
API Filtration Literature
Download the Pharmaceutical Preparations Filtration literature below for more details on our filtration solutions.
In the fine chemical industry, it is critical to filter process components to prevent particulate and microbial contamination, helping ensure product sterility and quality. Learn how Global Filter’s product solutions help to optimize the API process.