Active Pharmaceutical Ingredients (API) Filtration
We understand the impact improper filtration can have on the pharmaceutical preparations you produce and the overall adverse impact that substandard filtration can have on your business.
Optimizing the API Filtration Process
In the fine chemical industry, it is critical to filter process components to prevent particulate and microbial contamination, helping ensure product sterility and quality. Global Filter’s product solutions help protect the process from contaminants while extending service life and reducing operations costs. Global Filter designs and manufactures filter elements and vessels that are widely used in the API filtration. Our 50 years of industry expertise in the pharmaceutical preparations will help to optimize your manufacturing process.
Typical API Process
Filtration of API Upstream Process
Filtration of raw materials is important to ensure the best productivity during chemical reaction or treatment. Global Filter product range offers solutions to remove contaminants from solids particles to microorganisms from pharmaceutical preparations.
Firstly, for the particulate removal filter, we recommend using Global Filter’s GCTB-Series Meltblown cartridges along with the GTCH cartridge vessel.
Then, for the point of use particulate removal filter, we recommend using our pleated depth cartridge (PP-Series) with a GFHD mono cartridge vessel.
Moreover, we advice using a 0.2-micron rating PES membrane cartridge for microbial retention for the point of use sterilizing grade filter.
Finally, for the gas filter, it is recommended to use PPTFE-Series (Sterilizing grade) membrane cartridges along with the GSTL sanitary vessel.
Activated Carbon or Catalyst Removal
During production it could be necessary to add solids such as activ carbon or catalysis which
will be removed after the treatment or reaction. Depending on the solid quantity a first main step could be necessary to remove the majority of the catalysts . Amafilter’s Cricket filter is one of the best solution for this step. For small batches or after the main filtration we also offer several solutions in accordance with your process.
Our HFB-Series High Flow cartridge is one of the recommended solutions as it offers a safer and healthier option. Global Filter’s GHLS- Series pleated depth cartridge offers a reliable solution for catalysis recovering throughout its life time and especially after several cycles.
Crystalization and solvent filtration
In several steps of the pharmaceutical preparations’ process, solvents are necessary and producing high purity solvent on site can be really cost effective. The PP-Series pleated cartrides and GPFA-Series Membrane cartridges with absolute efficiencies down to 0.05 µm with high chemical compatibility are the best solutions to fulfill your requirements in terms of solvent filtration.
Literature
Download the Pharmaceutical Preprations Filtration literature below for more details on our filtration solutions.
In the fine chemical industry, it is critical to filter process components to prevent particulate and microbial contamination, helping ensure product sterility and quality. Learn how Global Filter’s product solutions help optimizing the API process.